we can use Silverlight(NPA PI). At the moment they have just disabled NPAPI, You can reenable it by:

entering 'chrome://flags' in Chrome's address bar
clicking 'enable' under 'Enable NPAPI'
clicking the 'relaunch now' button.

JavaScript:
Code:
if (Silverlight.isInstalled("5.0")) 
{
	var SilverlightActiveX;
	var strFile = "D:\\test.docx"
	document.getElementById("Silverlight").Value
...