mail sending failed in asp.net

[vasudevmahajan]

The message could not be sent to the SMTP server. The transport error code was 0x80040217. The server response was not available

[Plater]

The message could not be sent to the SMTP server. The transport error code was 0x80040217. The server response was not available

Well that's not a very good error message on their part, sounds like they're saying the smtp server didn't reply, or didn't reply with a valid response.

Does it do this everytime you try to send an email?
Do you know if the server you are using is a valid smtp server?

[Dharmaraju]

Please configure smtp server in your IIS server . with appropriate values
In your coding you should mention the smtp sever as "localhost or the ipaddress of that iis server

Please check it