PHP5 with MySQL 4.0 and 4.1 on different machines

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I want to setup PHP5 to access MySQL 4.0 on the local (Fedora 2) machine and
4.1 on a remote (OS X) machine. I've compiled PHP5 successfully using
'--with-mysql=/usr' to find the local MySQL 4.0 but what should I use to
configure a connection to the remote MySQL 4.1 server?

--with-mysqli=user:pas sword@osx:/path/to/mysql41

????

Can PHP5 even be configured to use both versions of MySQL?

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